Last edited by Akilmaran
Friday, July 10, 2020 | History

4 edition of Azapropazone found in the catalog.

Azapropazone

20 years of clinical use

  • 102 Want to read
  • 40 Currently reading

Published by Kluwer Academic Publishers in Dordrecht, Boston .
Written in English

    Subjects:
  • Azapropazone -- Testing.,
  • Azapropazone.,
  • Triazines -- therapeutic use.

  • Edition Notes

    Statementedited by K.D. Rainsford.
    ContributionsRainsford, K. D., 1941-
    Classifications
    LC ClassificationsRM666.A93 A93 1989
    The Physical Object
    Paginationxi, 295 p. :
    Number of Pages295
    ID Numbers
    Open LibraryOL2204799M
    ISBN 100792389115
    LC Control Number89026746

    Book. Jan ; K. D. Rainsford; View. Azapropazone (APZ) has been compared with standard NSAIDs in title systems to establish aspects of its mode of action on cellular events at inflamed. In a controlled clinical trial the effect of azapropazone ( mg. daily) was compared with placebo in 18 out-patients with ankylosing spondylitis. The trial was of “crossover” design, and results suggest that azapropazone may be of value in the symptomatic management of ankylosing spondylitis.

    azapropazone: A non-steroidal anti-inflammatory (NSAID) drug used in the treatment of conditions such as RHEUMATOID ARTHRITIS. A brand name is Rheumox. Thank you for your interest in spreading the word about The BMJ. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.

    More editions of Azapropazone: 20 Years of Clinical Use: Azapropazone: 20 Years of Clinical Use: ISBN () Softcover, Springer, The names of drugs are often formed by combining syllables taken from chemical sources so as to produce chemical-sounding names which, however, lack the meaning they would convey in a systematic context. Thus aza, prop, and one are all well known syllables combined in azapropazone to produce what is really a nonsense-word.


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Azapropazone Download PDF EPUB FB2

Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox. It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects.

Azopropazone has now been discontinued in the British National Formulary. Azapropazone has a half-life of approximately 20 hours in humans and Legal status: UK: POM (Prescription only). Azapropazone is a chemically unique non-steroidal anti-inflammatory drug (benzotriazine oxide) which has found successful clinical applications in the therapy of a wide variety of arthritic conditions.

This book summarizes the progress and critically reviews the clinical use and experimental studies since its introduction 20 years ago. Azapropazone seems to be a safe alternative in these patients, Azapropazone book a study that showed good tolerance of the drug in patients with aspirin intolerance [8].

View chapter Purchase book. Tolerance of azapropazone: allergic and pseudo-allergic reactions and comparison with other NSAIDs A. Szczeklik, E. Nizankowska, G. Czerniawska-Mysik Pages Though it has not become widely used, azapropazone () has some use in the treatment of rheumatic disease and other muscoskeletal disorders 〈69AF36〉.A similar compound, called cinnopentazone (), has antiinflammatory activity but it is also significantly active against some tumors 〈70AF〉.FKK (), a selected compound from a series of pyrazoloindazolium halides, is an active.

azapropazone azapropazone dihydrate apazone cinnamin cinnopropazone prolixan Orange Book patent data (new drug applications) None. Orange Book exclusivity data (new drug applications) None. Bioactivity Summary: Target Class Pharos UniProt Action Type Activity value (-log[M]) Mechanism.

Azapropazone Azapropazone book Kim D. Rainsford,available at Book Depository with free delivery worldwide. Section I Experimental.- 1 Introduction to therapy with azapropazone.- 2 The chemical classification of azapropazone.- 3 Survey of toxicological investigations of azapropazone.- 4 The mode of action of azapropazone in relation to its therapeutic actions in rheumatic conditions and its major side-effects.- 5 Pharmacokinetic properties of.

Three methods for the determination of azapropazone were studied for the analysis of blood plasma samples taken after oral administration of azapropazone. A gas chromatographic method was compared with two simple spectrophotometric assay methods and the effect of metabolites of the drug on each method is described.

Azapropazone was absorbed from the gastro-intestinal tract in animals and man, although wide interspecies variation in pharmacokinetic properties was noted. In man, the biological half life was approximately 20 hours.

Azapropazone is not extensively metabolised and most metabolites have been identified and assayed. Azapropazon je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu odDa. Apazone (azapropazone) is not approved for marketing in the United States by the U.S.

Food and Drug Administration. Relatively small amounts of the drug are excreted into breastmilk; however, the toxicity of the drug limits its usefulness in nursing mothers. An alternate drug is preferred, especially while nursing a newborn or preterm infant.

ISBN: OCLC Number: Description: 1 online resource ( pages) Contents: Section I Experimental.- 1 Introduction to therapy with azapropazone.- 2 The chemical classification of azapropazone.- 3 Survey of toxicological investigations of azapropazone.- 4 The mode of action of azapropazone in relation to its therapeutic.

Definition of azapropazone in the dictionary. Meaning of azapropazone. What does azapropazone mean. Information and translations of azapropazone in the most comprehensive dictionary definitions resource on the web.

Azapropazone is a non-steroidal anti-inflammatory drug and was first launched in We have found only one published case report of photosensitivity during treatment with azapropazone.

Azapropazone itself, 5-(dimethylamino)methylpropyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, has previously been shown to be nonplanar, probably due to steric interactions between the pyrazolidine ring and the exocyclic dimethylamino group.

The derivative studied in this work, 3-dimethylaminomethyl-1,2,4-benzotriazine, does. Azapropazone British Pharmacopoeia (BP) Reference Standard Synonym: 5-(Dimethylamino)methylpropyl-1H-pyrazolo[1,2-a] [1,2,4] benzotriazine-1,3(2H)-dione CAS Number Empirical Formula (Hill Notation) C 16 H 20 N 4 O 2.

Molecular Weight Azapropazone clearance correlated well with creatinine clearance (P less than ) when all the subjects were included and for the younger subjects only but not for the elderly patients alone.

The addition of fat mass into the regression equation improved the relationship in all groups but in the older group levels of statistical significance.

Azapropazone Scheme. ATC (Anatomical Therapeutic Chemical Classification) M01AX CAS registry number (Chemical Abstracts Service) Chemical Formula. CHN4-O2. Molecular Weight. Therapeutic Categories. Analgesic, antipyretic and anti-inflammatory agent.

Non-steroidal anti-inflammatory drug, NSAID. Chemical Name. Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox.

[1] It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects. [2] Azopropazone has now been discontinued in the British National Formulary. Azapropazone has a half-life of approximately 20 hours in.

Azapropazone's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage: mg: () 12 hourly: PO: The dose can be decreased to mg/day and incresed upto mg/day.

For renal impaired function: Starting dose is mg in the morning and mg at night.provides accurate and independent information on more t prescription drugs, over-the-counter medicines and natural products.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 30 June ), Cerner Multum™ (updated 1 July ), Wolters Kluwer.Description: Azapropazone is an NSAID structurally related to phenylbutazone which also has uricosuric properties.

MIMS Class. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Disclaimer: This information is independently developed by MIMS based on Azapropazone from various references and is provided for your reference only.